Research Group: Biofabrication
The aim of the Group is to develop 3D artificial matrices, in vitrobiological models, and smart micro/nano-systems for applications in tissue engineering and cancer. The Group focuses on the development of multifunctional biomaterials and biofabrication strategies to generate versatile biomimetic platforms to study cell-material interactions underlying healthy and diseased tissues, translating this knowledge to create cutting-edge solutions for tissue repair and cancer diagnosis and treatment.
The Group’s research is developed in several areas, namely multifunctional biomaterials, biofabrication strategies – namely 3D bioprinting and electrospinning -, organ-on-a-chip devices, advanced bioengineered platforms, and tissue engineering applications. Biomaterials play a central role in most biomedical applications, acting as cell-instructive matrices and/or delivery vehicles of cells, drugs and biomolecules. Our Group is developing new biomaterials with controllable properties capable of guiding de novotissue formation. Novel biomaterials with multifunctional properties, dynamic and viscoelastic behaviors are being synthetized by exploring a variety of chemistries to recreate fundamental functions of the native extracellular matrix. These biomaterials are being applied to develop advanced bioinks, 3D cell culture platforms, matrices for tissue regeneration and micro/nanoparticulate systems.
Bioprinting is a core technology in biofabrication enabling the automated generation of biologically functional 3D constructs. The Group is working on the development of bioprinting technologies combining modular printing units to produce 3D cell-laden constructs, cell-instructive 3D scaffolds and in vitrotissue models. By utilizing bioprinting systems we are able to control the spatial arrangement of cells, biomaterials and biomolecules towards the fabrication of biomimetic 3D constructs. Our team is combining bioinstructive biomaterials and cells to fabricate3D constructs for skin, stomach and bone regeneration.
Another area of research is the use of microfluidic technology to create miniaturized organs-on-a-chip platforms resembling fundamental features of human organs. Biomimetic platforms are a valuable tool to perform in vitrostudies to understand fundamental mechanisms underlying healthy and diseased tissues. We are combining cell-derived matrices, engineered biomaterials, cells and bioprinting technology to create in vitro3D tissue models and artificial 3D cell culture systems to study the transport of nanoparticles and cell-cell/cell-material interactions. These platforms are essential to develop more efficient strategies for cancer and tissue repair (e.g., stomach ulcers, chronic skin wounds).
- 3D bioprinting
- Regenerative Medicine, Tissue Engineering, Biomaterials
- Molecularly-designed hydrogels
- Microfluidics and organ-on-chip devices
- Cell immobilization/encapsulation (3D cell culture)
- Bone and skin regeneration
- Artificial extracellular matrix
- Injectable materials
- Intercellular crosstalking
- Stem cells (substrate-mediated guidance of stem cells fate)
- Stomach engineering