Terahertz spectroscopy for the study of paraffin-embedded gastric cancer samples
Wahaia F, Kasalynas I, Siliuta D, Molis G, Urbanovic A, Silva CDC, Carneiro F, Valusis G, Granja PL. J Mol Struct, 2015.
Terahertz (THz) spectroscopy constitute promising technique for biomedical applications as a complementary and powerful tool for diseases screening specially for early cancer diagnostic. The THz radiation is not harmful to biological tissues. As increased blood supply in cancer-affected tissues and consequent local increase in tissue water content makes THz technology a potentially attractive. In the present work, samples of healthy and adenocarcinoma-affected gastric tissue were analyzed using transmission time-domain THz spectroscopy (THz-TDS). The work shows the capability of the technique to distinguish between normal and cancerous regions in dried and paraffin-embedded samples. Plots of absorption coefficient a and refractive index n of normal and cancer affected tissues, are presented and the conditions for discrimination between normal and affected tissues are discussed.
Additional information: Wahaia et al, J Mol Struct 2015;1079:391-5.